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Coccarelli A, Pant S, Polydoros I, Harraz OF. Correction to: A new model for evaluating pressure‑induced vascular tone in small cerebral arteries. Biomech Model Mechanobiol. 2024 Apr;23(2):707. doi: 10.1007/s10237-023-01795-2. PubMed PMID: 38358396; PubMed Central PMCID: PMC10963469.
Sancho M, Klug NR, Harraz OF, Hill-Eubanks D, Nelson MT. Distinct potassium channel types in brain capillary pericytes. Biophys J. 2024 Mar 5;. doi: 10.1016/j.bpj.2024.03.004. [Epub ahead of print] PubMed PMID: 38444160; NIHMSID:NIHMS1980485.
Lim XR, Harraz OF. Mechanosensing by Vascular Endothelium. Annu Rev Physiol. 2024 Feb 12;86:71-97. doi: 10.1146/annurev-physiol-042022-030946. Epub 2023 Oct 20. Review. PubMed PMID: 37863105; PubMed Central PMCID: PMC10922104.
Coccarelli A, Pant S, Polydoros I, Harraz OF. A new model for evaluating pressure-induced vascular tone in small cerebral arteries. Biomech Model Mechanobiol. 2024 Feb;23(1):271-286. doi: 10.1007/s10237-023-01774-7. Epub 2023 Nov 4. PubMed PMID: 37925376; PubMed Central PMCID: PMC10901969.
Harraz OF, Delpire E. Recent insights into channelopathies. Physiol Rev. 2024 Jan 1;104(1):23-31. doi: 10.1152/physrev.00022.2023. Epub 2023 Aug 10. PubMed PMID: 37561136.
Grandi E, Navedo MF, Saucerman JJ, Bers DM, Chiamvimonvat N, Dixon RE, Dobrev D, Gomez AM, Harraz OF, Hegyi B, Jones DK, Krogh-Madsen T, Murfee WL, Nystoriak MA, Posnack NG, Ripplinger CM, Veeraraghavan R, Weinberg S. Diversity of cells and signals in the cardiovascular system. J Physiol. 2023 Jul;601(13):2547-2592. doi: 10.1113/JP284011. Epub 2023 Feb 16. PubMed PMID: 36744541; PubMed Central PMCID: PMC10313794.
Harraz OF. Endothelial Cell Metabolism and Vascular Function: A Paradigm Shift?. Function (Oxf). 2023;4(2):zqad002. doi: 10.1093/function/zqad002. eCollection 2023. PubMed PMID: 36778750; PubMed Central PMCID: PMC9909363.
Bracko O, Harraz OF. Editorial: Small and mighty: Brain capillaries in health and disease. Front Mol Neurosci. 2022;15:1108978. doi: 10.3389/fnmol.2022.1108978. eCollection 2022. PubMed PMID: 36583082; PubMed Central PMCID: PMC9792964.
Harraz OF, Klug NR, Senatore AJ, Hill-Eubanks DC, Nelson MT. Piezo1 Is a Mechanosensor Channel in Central Nervous System Capillaries. Circ Res. 2022 May 13;130(10):1531-1546. doi: 10.1161/CIRCRESAHA.122.320827. Epub 2022 Apr 6. PubMed PMID: 35382561; PubMed Central PMCID: PMC9106929.
Harraz OF, Jensen LJ. Vascular calcium signalling and ageing. J Physiol. 2021 Dec;599(24):5361-5377. doi: 10.1113/JP280950. Epub 2021 Nov 21. Review. PubMed PMID: 34705288; PubMed Central PMCID: PMC9002240.
Koide M, Harraz OF, Dabertrand F, Longden TA, Ferris HR, Wellman GC, Hill-Eubanks DC, Greenstein AS, Nelson MT. Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease. J Clin Invest. 2021 Sep 15;131(18). doi: 10.1172/JCI149029. PubMed PMID: 34351870; PubMed Central PMCID: PMC8439604.
Longden TA, Mughal A, Hennig GW, Harraz OF, Shui B, Lee FK, Lee JC, Reining S, Kotlikoff MI, König GM, Kostenis E, Hill-Eubanks D, Nelson MT. Local IP(3) receptor-mediated Ca(2+) signals compound to direct blood flow in brain capillaries. Sci Adv. 2021 Jul;7(30). doi: 10.1126/sciadv.abh0101. Print 2021 Jul. PubMed PMID: 34290098; PubMed Central PMCID: PMC8294755.
Betrie AH, Brock JA, Harraz OF, Bush AI, He GW, Nelson MT, Angus JA, Wright CE, Ayton S. Zinc drives vasorelaxation by acting in sensory nerves, endothelium and smooth muscle. Nat Commun. 2021 Jun 1;12(1):3296. doi: 10.1038/s41467-021-23198-6. PubMed PMID: 34075043; PubMed Central PMCID: PMC8169932.
Dabertrand F, Harraz OF, Koide M, Longden TA, Rosehart AC, Hill-Eubanks DC, Joutel A, Nelson MT. PIP(2) corrects cerebral blood flow deficits in small vessel disease by rescuing capillary Kir2.1 activity. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17). doi: 10.1073/pnas.2025998118. PubMed PMID: 33875602; PubMed Central PMCID: PMC8092380.
Sackheim AM, Villalba N, Sancho M, Harraz OF, Bonev AD, D'Alessandro A, Nemkov T, Nelson MT, Freeman K. Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels. Function (Oxf). 2021;2(3). doi: 10.1093/function/zqab018. Epub 2021 Apr 6. PubMed PMID: 34568829; PubMed Central PMCID: PMC8462507.
Mughal A, Harraz OF, Gonzales AL, Hill-Eubanks D, Nelson MT. PIP(2) Improves Cerebral Blood Flow in a Mouse Model of Alzheimer's Disease. Function (Oxf). 2021;2(2):zqab010. doi: 10.1093/function/zqab010. eCollection 2021. PubMed PMID: 33763649; PubMed Central PMCID: PMC7955025.
Harraz OF, Jensen LJ. Aging, calcium channel signaling and vascular tone. Mech Ageing Dev. 2020 Oct;191:111336. doi: 10.1016/j.mad.2020.111336. Epub 2020 Sep 9. Review. PubMed PMID: 32918949; PubMed Central PMCID: PMC8511598.
Harraz OF, Hill-Eubanks D, Nelson MT. PIP(2): A critical regulator of vascular ion channels hiding in plain sight. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20378-20389. doi: 10.1073/pnas.2006737117. Epub 2020 Aug 6. Review. PubMed PMID: 32764146; PubMed Central PMCID: PMC7456132.
Moshkforoush A, Ashenagar B, Harraz OF, Dabertrand F, Longden TA, Nelson MT, Tsoukias NM. The capillary Kir channel as sensor and amplifier of neuronal signals: Modeling insights on K(+)-mediated neurovascular communication. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16626-16637. doi: 10.1073/pnas.2000151117. Epub 2020 Jun 29. PubMed PMID: 32601236; PubMed Central PMCID: PMC7368319.
Gomes CC, Gayden T, Bajic A, Harraz OF, Pratt J, Nikbakht H, Bareke E, Diniz MG, Castro WH, St-Onge P, Sinnett D, Han H, Rivera B, Mikael LG, De Jay N, Kleinman CL, Valera ET, Bassenden AV, Berghuis AM, Majewski J, Nelson MT, Gomez RS, Jabado N. TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw. Nat Commun. 2018 Nov 1;9(1):4572. doi: 10.1038/s41467-018-06690-4. PubMed PMID: 30385747; PubMed Central PMCID: PMC6212533.
Hashad AM, Harraz OF, Brett SE, Romero M, Kassmann M, Puglisi JL, Wilson SM, Gollasch M, Welsh DG. Caveolae Link Ca(V)3.2 Channels to BK(Ca)-Mediated Feedback in Vascular Smooth Muscle. Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2371-2381. doi: 10.1161/ATVBAHA.118.311394. PubMed PMID: 30354206.
Harraz OF, Longden TA, Hill-Eubanks D, Nelson MT. PIP(2) depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells. Elife. 2018 Aug 7;7. doi: 10.7554/eLife.38689. PubMed PMID: 30084828; PubMed Central PMCID: PMC6117155.
Harraz OF, Longden TA, Dabertrand F, Hill-Eubanks D, Nelson MT. Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP(2) depletion. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3569-E3577. doi: 10.1073/pnas.1800201115. Epub 2018 Mar 26. PubMed PMID: 29581272; PubMed Central PMCID: PMC5899484.
Hashad AM, Mazumdar N, Romero M, Nygren A, Bigdely-Shamloo K, Harraz OF, Puglisi JL, Vigmond EJ, Wilson SM, Welsh DG. Interplay among distinct Ca(2+) conductances drives Ca(2+) sparks/spontaneous transient outward currents in rat cerebral arteries. J Physiol. 2017 Feb 15;595(4):1111-1126. doi: 10.1113/JP273329. Epub 2016 Dec 12. PubMed PMID: 27805790; PubMed Central PMCID: PMC5309379.
Harraz OF, Brett SE, Zechariah A, Romero M, Puglisi JL, Wilson SM, Welsh DG. Genetic ablation of CaV3.2 channels enhances the arterial myogenic response by modulating the RyR-BKCa axis. Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):1843-51. doi: 10.1161/ATVBAHA.115.305736. Epub 2015 Jun 11. PubMed PMID: 26069238; PubMed Central PMCID: PMC5117108.
Harraz OF, Visser F, Brett SE, Goldman D, Zechariah A, Hashad AM, Menon BK, Watson T, Starreveld Y, Welsh DG. CaV1.2/CaV3.x channels mediate divergent vasomotor responses in human cerebral arteries. J Gen Physiol. 2015 May;145(5):405-18. doi: 10.1085/jgp.201511361. PubMed PMID: 25918359; PubMed Central PMCID: PMC4411256.
Harraz OF, Abd El-Rahman RR, Bigdely-Shamloo K, Wilson SM, Brett SE, Romero M, Gonzales AL, Earley S, Vigmond EJ, Nygren A, Menon BK, Mufti RE, Watson T, Starreveld Y, Furstenhaupt T, Muellerleile PR, Kurjiaka DT, Kyle BD, Braun AP, Welsh DG. Ca(V)3.2 channels and the induction of negative feedback in cerebral arteries. Circ Res. 2014 Sep 12;115(7):650-61. doi: 10.1161/CIRCRESAHA.114.304056. Epub 2014 Aug 1. PubMed PMID: 25085940; PubMed Central PMCID: PMC4527613.
Harraz OF, Altier C. STIM1-mediated bidirectional regulation of Ca(2+) entry through voltage-gated calcium channels (VGCC) and calcium-release activated channels (CRAC). Front Cell Neurosci. 2014;8:43. doi: 10.3389/fncel.2014.00043. eCollection 2014. Review. PubMed PMID: 24605083; PubMed Central PMCID: PMC3932444.
Harraz OF, Brett SE, Welsh DG. Nitric oxide suppresses vascular voltage-gated T-type Ca2+ channels through cGMP/PKG signaling. Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H279-85. doi: 10.1152/ajpheart.00743.2013. Epub 2013 Nov 15. PubMed PMID: 24240871.
Harraz OF, Welsh DG. Protein kinase A regulation of T-type Ca2+ channels in rat cerebral arterial smooth muscle. J Cell Sci. 2013 Jul 1;126(Pt 13):2944-54. doi: 10.1242/jcs.128363. Epub 2013 Apr 23. PubMed PMID: 23613468.
Harraz OF, Welsh DG. T-type Ca²⁺ channels in cerebral arteries: approaches, hypotheses, and speculation. Microcirculation. 2013 May;20(4):299-306. doi: 10.1111/micc.12038. Review. PubMed PMID: 23331671.
Abd El-Rahman RR, Harraz OF, Brett SE, Anfinogenova Y, Mufti RE, Goldman D, Welsh DG. Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development. Am J Physiol Heart Circ Physiol. 2013 Jan 1;304(1):H58-71. doi: 10.1152/ajpheart.00476.2012. Epub 2012 Oct 26. PubMed PMID: 23103495; PubMed Central PMCID: PMC3543679.
Harraz OF, El-Gowelli HM, Mohy El-Din MM, Ghazal AR, El-Mas MM. Adenosinergic modulation of the imidazoline I₁-receptor-dependent hypotensive effect of ethanol in acute renal failure. Food Chem Toxicol. 2012 Aug;50(8):2622-8. doi: 10.1016/j.fct.2012.05.015. Epub 2012 May 18. PubMed PMID: 22613216.
Anfinogenova Y, Brett SE, Walsh MP, Harraz OF, Welsh DG. Do TRPC-like currents and G protein-coupled receptors interact to facilitate myogenic tone development?. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1378-88. doi: 10.1152/ajpheart.00460.2011. Epub 2011 Aug 5. PubMed PMID: 21821777.
El-Mas MM, El-Gowelli HM, Ghazal AR, Harraz OF, Mohy El-Din MM. Facilitation of central imidazoline I(1)-site/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase signalling mediates the hypotensive effect of ethanol in rats with acute renal failure. Br J Pharmacol. 2009 Nov;158(6):1629-40. doi: 10.1111/j.1476-5381.2009.00444.x. Epub 2009 Oct 20. PubMed PMID: 19845670; PubMed Central PMCID: PMC2795229.
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