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‘Relieved’: Health care workers begin receiving COVID-19 vaccine as largest vaccination campaign in US history now underway

  • Jon Horton, Sentara director of pharmacy operations, unpacks boxes of...

    Stephen M. Katz/The Virginian-Pilot

    Jon Horton, Sentara director of pharmacy operations, unpacks boxes of Pfizer's COVID-19 vaccination Dec. 14, 2020, morning in Norfolk, Virginia.

  • Dr. Lyudmila Soboleva is inoculated with Russia's Sputnik V vaccine...

    Sergey Ponomarev/The New York Times

    Dr. Lyudmila Soboleva is inoculated with Russia's Sputnik V vaccine for COVID-19, in Moscow on Dec. 7, 2020. Distrust of the government is so widespread that 59% of Russians say they have no intention of getting country's coronavirus vaccine.

  • Dr. Michelle Chester draws the Pfizer-BioNTech COVID-19 vaccine into a...

    Mark Lennihan/AP

    Dr. Michelle Chester draws the Pfizer-BioNTech COVID-19 vaccine into a syringe at Long Island Jewish Medical Center on Dec. 14, 2020, in the Queens borough of New York.

  • Registered Nurse Danielle Parker wipes a tear away as she...

    Bob Self/Florida Times-Union

    Registered Nurse Danielle Parker wipes a tear away as she sits during the waiting period after getting her COVID-19 vaccination, Dec. 14, 2020. Parker has been a nurse in the COVID-19 ICU since the pandemic started. Parker became emotional after getting her shot and said "It's taken a large toll on the whole unit".

  • Colleen Claffey, a Memorial Health nurse, inoculates front line worker...

    Susan Stocker / South Florida Sun Sentinel

    Colleen Claffey, a Memorial Health nurse, inoculates front line worker Dr. Kiesha Raphael on Monday Dec. 14, 2020 in Miramar, Fl. Memorial is one of only five healthcare systems in Florida chosen as host for the Pfizer-Biontech vaccine.

  • A sign spells out a mask requirement in Sacramento, California,...

    Max Whittaker / The New York Times

    A sign spells out a mask requirement in Sacramento, California, on Dec. 5, 2020. Scientists worry that if vaccinated people are silent spreaders of the virus, they may keep it circulating in their communities, putting unvaccinated people at risk.

  • People are given the Pfizer-BioNTech COVID-19 vaccine in Cardiff, Wales,...

    Andrew Testa / The New York Times

    People are given the Pfizer-BioNTech COVID-19 vaccine in Cardiff, Wales, on Dec. 8, 2020.

  • Boxes containing the Pfizer-BioNTech COVID-19 vaccine are prepared to be...

    Morry Gash/AP

    Boxes containing the Pfizer-BioNTech COVID-19 vaccine are prepared to be shipped at the Pfizer Global Supply Kalamazoo manufacturing plant in Portage, Michigan, on Dec. 13, 2020.

  • Pharmacists wheel a box containing the Pfizer-BioNTech COVID-19 vaccine to...

    David Goldman/AP

    Pharmacists wheel a box containing the Pfizer-BioNTech COVID-19 vaccine to a freezer as it arrives at Rhode Island Hospital in Providence on Dec. 14, 2020.

  • Mayor Bill de Blasio bumps forearms with Tara Easter, a...

    Kevin Hagen / AP

    Mayor Bill de Blasio bumps forearms with Tara Easter, a registered nurse at NYU-Langone Hospital who received the COVID-19 vaccine, Dec. 14, 2020, in New York.

  • Henry Vokes, 98, reacts after receiving the Pfizer-BioNTech COVID-19 vaccine...

    Graeme Robertson/The Guardian/AP

    Henry Vokes, 98, reacts after receiving the Pfizer-BioNTech COVID-19 vaccine at Southmead Hospital, Bristol, England, on Dec. 8, 2020.

  • David Conway, a registered nurse in the emergency department at...

    Joseph Cress/Iowa City Press-Citizen

    David Conway, a registered nurse in the emergency department at the University of Iowa Hospitals and Clinics (UIHC), receives the first dose of the Pfizer-BioNTech COVID-19 vaccine at the hospital from registered nurse Rachel Lewis, Dec. 14, 2020, on the 12th floor of the University of Iowa Stead Family Children's Hospital in Iowa City, Iowa.

  • Medical staff in booths prepare to administer the Pfizer-BioNTech COVID-19...

    Justin Tallis/AP

    Medical staff in booths prepare to administer the Pfizer-BioNTech COVID-19 vaccine at a vaccination center in Cardiff, Wales on Dec. 8, 2020.

  • The first doses of the Pfizer-BioNTech COVID-19 vaccine are delivered...

    Ryan Remiorz/AP

    The first doses of the Pfizer-BioNTech COVID-19 vaccine are delivered to the Maimonides CHSLD on Dec. 14, 2020, in Montreal, Canada. The long-term care facility is slated to be one of the first in Canada to administer the vaccine.

  • A nurse prepares to administer the Pfizer-BioNTech COVID-19 vaccine at...

    Frank Augstein/AP

    A nurse prepares to administer the Pfizer-BioNTech COVID-19 vaccine at Guy's Hospital in London on Dec. 8, 2020. U.K. health authorities rolled out the first doses of a widely tested and independently reviewed COVID-19 vaccine, starting a global immunization program that is expected to gain momentum as more vaccines win approval.

  • Care home worker Pillay Jagambrun, 61, receives the Pfizer/BioNTech COVID-19...

    Dan Charity/AP

    Care home worker Pillay Jagambrun, 61, receives the Pfizer/BioNTech COVID-19 vaccine Dec. 8, 2020, in the Vaccination Hub at Croydon University Hospital, south London, on the first day of the largest immunization program in U.K. history.

  • Boxes containing the Pfizer-BioNTech COVID-19 vaccine are prepared to be...

    Morry Gash/AP

    Boxes containing the Pfizer-BioNTech COVID-19 vaccine are prepared to be shipped at the Pfizer Global Supply Kalamazoo manufacturing plant in Portage, Michigan, on Dec. 13, 2020.

  • Nurse Marylou Oshana administers the Pfizer-BioNTech vaccine for COVID-19 to...

    Jessica Hill/AP

    Nurse Marylou Oshana administers the Pfizer-BioNTech vaccine for COVID-19 to Dr. Ajay Kumar, executive vice president and chief clinical officer for Hartford HealthCare, outside Hartford Hospital, Dec. 14, 2020, in Hartford, Conn.

  • Sandra Lindsay, left, a nurse at Long Island Jewish Medical...

    Mark Lennihan/AP

    Sandra Lindsay, left, a nurse at Long Island Jewish Medical Center, is inoculated with the Pfizer-BioNTech COVID-19 vaccine by Dr. Michelle Chester on Dec. 14, 2020, in the Queens borough of New York.

  • Clinical research nurse Samantha Gatewood administers the second shot in...

    E. Jason Wambsgans / Chicago Tribune

    Clinical research nurse Samantha Gatewood administers the second shot in an AstraZeneca vaccine trial at Rush University Medical Center on Dec. 3, 2020.

  • Discarded bottles of the Pfizer-BioNTech COVID-19 vaccine in Cardiff, Wales,...

    Andrew Testa/The New York Times

    Discarded bottles of the Pfizer-BioNTech COVID-19 vaccine in Cardiff, Wales, on Dec. 8, 2020.

  • Dr. Michelle Chester holds a vial of the Pfizer-BioNTech COVID-19...

    Mark Lennihan/AP

    Dr. Michelle Chester holds a vial of the Pfizer-BioNTech COVID-19 vaccine at Long Island Jewish Medical Center on Dec. 14, 2020, in the Queens borough of New York.

  • Nurse Annabelle Jimenez, left, congratulates nurse Sandra Lindsay after she...

    Mark Lennihan/AP

    Nurse Annabelle Jimenez, left, congratulates nurse Sandra Lindsay after she was inoculated with the Pfizer-BioNTech COVID-19 vaccine Dec. 14, 2020, at the Jewish Medical Center, in the Queens borough of New York.

  • Dr. Michelle Chester draws the Pfizer-BioNTech COVID-19 vaccine into a...

    Mark Lennihan/AP

    Dr. Michelle Chester draws the Pfizer-BioNTech COVID-19 vaccine into a syringe at Long Island Jewish Medical Center, Monday, Dec. 14, 2020, in the Queens borough of New York.

  • Robin Mercier, a Lifespan Health Care registered nurse, receives a...

    Elise Amendola/AP

    Robin Mercier, a Lifespan Health Care registered nurse, receives a new COVID-19 vaccine, Dec. 14, 2020, in Providence, R.I.

  • A sign on the entrance to a pharmacy reads "COVID-19...

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    A sign on the entrance to a pharmacy reads "COVID-19 vaccine not yet available" on Nov. 23, 2020, in Burbank, California.

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The largest vaccination campaign in U.S. history got underway Monday as health workers in select hospitals rolled up their sleeves for shots to protect them from COVID-19 and start beating back the pandemic — a day of optimism even as the nation’s death toll neared 300,000.

“I feel hopeful today. Relieved,” said critical case nurse Sandra Lindsay after getting a shot in the arm at Long Island Jewish Medical Center in New York.

Shipments of precious frozen vials of vaccine made by Pfizer Inc. and its German partner BioNTech began arriving at hospitals around the country Monday.

“This is the light at the end of the tunnel. But it’s a long tunnel,” New York Gov. Andrew Cuomo said as he watched Lindsay’s vaccination via video.

Several other countries also have OK’d the vaccine, including the U.K., which started vaccinating last week.

For health care workers who, along with nursing home residents, will be first in line for vaccination, hope is tempered by grief and the sheer exhaustion of months spent battling a coronavirus that still is surging in the U.S. and around the world.

“This is mile 24 of a marathon. People are fatigued. But we also recognize that this end is in sight,” said Dr. Chris Dale of Swedish Health Services in Seattle.

Packed in dry ice to stay at ultra-frozen temperatures, the first of nearly 3 million doses being shipped in staggered batches this week made their way by truck and by plane around the country Sunday from Pfizer’s Kalamazoo, Michigan, factory. Once they arrive at distribution centers, each state directs where the doses go next.

Some hospitals across the country spent the weekend tracking their packages, refreshing FedEx and UPS websites for clues.

More of the Pfizer-BioNTech vaccine will arrive each week. And later this week, the FDA will decide whether to green light the world’s second rigorously studied COVID-19 vaccine, made by Moderna Inc.

Now the hurdle is to rapidly get vaccine into the arms of millions, not just doctors and nurses but other at-risk health workers such as janitors and food handlers — and then deliver a second dose three weeks later.

“We’re also in the middle of a surge, and it’s the holidays, and our health care workers have been working at an extraordinary pace,” said Sue Mashni, chief pharmacy officer at Mount Sinai Health System in New York City.

Plus, the shots can cause temporary fever, fatigue and aches as they rev up people’s immune systems, forcing hospitals to stagger employee vaccinations.

A wary public will be watching closely to see whether health workers embrace vaccination. Just half of Americans say they want to get vaccinated, while about a quarter don’t and the rest are unsure, according to a recent poll by The Associated Press-NORC Center for Public Health Research.

The FDA, considered the world’s most strict medical regulator, said the Pfizer-BioNTech vaccine appears safe and strongly protective — and laid out the data behind it in a daylong public meeting last week for scientists and consumers alike to see.

“Please people, when you look back in a year and you say to yourself, ‘Did I do the right thing?’ I hope you’ll be able to say, ‘Yes, because I looked at the evidence,'” Dr. Francis Collins, director of the National Institutes of Health, said Sunday on NBC’s Meet the Press. “People are dying right now. How could you possibly say, ‘Let’s wait and see.'”

Still, emergency use means the vaccine was cleared for widespread use before a final study in nearly 44,000 people is complete — and that research is continuing to try to answer additional questions. While effective against COVID-19 illness, it’s not yet clear if vaccination will stop the symptomless spread that accounts for half of all cases.

The shots still must be studied in children, and during pregnancy. But the American College of Obstetricians and Gynecologists said late Sunday that vaccination should not be withheld from pregnant women who otherwise would qualify.

While the vaccine was determined to be safe, regulators in the U.K. are investigating several severe allergic reactions. The FDA’s instructions tell providers not to give it to those with a known history of severe allergic reactions to any of its ingredients.

AP journalists Tamara Lush and Kathy Young contributed to this report.

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content.