Clinical Practice GuidelinesDelphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines
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open access
Graphical abstract
Keywords
Recommendation
Clinical
Young
50 Years
Colorectal Cancer
Abbreviations used in this paper
ADR
adenoma detection rate
CI
confidence interval
CINV
chemotherapy-induced nausea and vomiting
CRC
colorectal cancer
DIRECt
Delphi Initiative Recommendations on EoCRC
eoCRC
early-onset colorectal cancer
ESGE
European Society of Gastrointestinal Endoscopy
ESMO
European Society of Medical Oncology
FIT
fecal immunochemical testing
GI
gastrointestinal
IHC
immunohistochemistry
LE
level of evidence
loCRC
late-onset colorectal cancer
LPV
likely pathogenic variants
LS
Lynch syndrome
MMR
mismatch repair
MMR-d
mismatch repair deficiency
MMR-p
mismatch repair proficiency
MSI
microsatellite instability
MSI-H
microsatellite instability high
NCCN
National Comprehensive Cancer Network
NGS
next-generation sequencing
OR
odds ratio
PICO
population, intervention, comparison, and outcome
PRS
polygenic risk scores
PV
pathogenic variants
RR
relative risk
SNP
single nucleotide polymorphism
USMSTF
U.S. Multi-Society Task Force
USPSTF
U.S. Preventive Service Task Force
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Conflicts of interest Refer to the online form to see conflicts of interest.
This article has an accompanying continuing medical education activity, also eligible for MOC credit, on page e7. Upon completion of this module, successful learners will be able to evaluate high-risk symptoms of early-onset colorectal cancer, explain the utility of tumor testing and germline testing in this setting, integrate the oncological management with the fertility management, and cite the surveillance protocol after cure from colorectal cancer <50 years.
- ∗
Authors share co-first authorship.
- ‡
Chairs of the Working Panels.
© 2022 by the AGA Institute. Published by Elsevier Inc. on behalf of the AGA Institute.