Extracellular vesicles from human iPSC-derived neural stem cells: miRNA and protein signatures, and anti-inflammatory and neurogenic properties R Upadhya, LN Madhu, S Attaluri, DLG Gitaí, MR Pinson, M Kodali, ... Journal of extracellular vesicles 9 (1), 1809064, 2020 | 104 | 2020 |
Human induced pluripotent stem cell-derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration D Upadhya, B Hattiangady, OW Castro, B Shuai, M Kodali, S Attaluri, ... Proceedings of the National Academy of Sciences 116 (1), 287-296, 2019 | 99 | 2019 |
Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus M Kodali, S Attaluri, LN Madhu, B Shuai, R Upadhya, JJ Gonzalez, X Rao, ... Aging Cell 20 (2), e13277, 2021 | 93 | 2021 |
Intranasally administered human MSC-derived extracellular vesicles pervasively incorporate into neurons and microglia in both intact and status epilepticus injured forebrain M Kodali, OW Castro, DK Kim, A Thomas, B Shuai, S Attaluri, R Upadhya, ... International journal of molecular sciences 21 (1), 181, 2019 | 87 | 2019 |
Chronic oxidative stress, mitochondrial dysfunction, Nrf2 activation and inflammation in the hippocampus accompany heightened systemic inflammation and oxidative stress in an … GA Shetty, B Hattiangady, D Upadhya, A Bates, S Attaluri, B Shuai, ... Frontiers in molecular neuroscience 10, 182, 2017 | 85 | 2017 |
Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood LN Madhu, S Attaluri, M Kodali, B Shuai, R Upadhya, D Gitai, AK Shetty Brain, behavior, and immunity 81, 430-443, 2019 | 70 | 2019 |
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus LN Madhu, M Kodali, S Attaluri, B Shuai, L Melissari, X Rao, AK Shetty Redox Biology 43, 101973, 2021 | 65 | 2021 |
Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro-and systemic inflammation in a model of Gulf War Illness AK Shetty, S Attaluri, M Kodali, B Shuai, GA Shetty, D Upadhya, ... Redox biology 28, 101389, 2020 | 49 | 2020 |
A model of chronic temporal lobe epilepsy presenting constantly rhythmic and robust spontaneous seizures, co-morbidities and hippocampal neuropathology D Upadhya, M Kodali, D Gitai, OW Castro, G Zanirati, R Upadhya, ... Aging and disease 10 (5), 915, 2019 | 31 | 2019 |
Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction M Kodali, LN Madhu, RL Reger, B Milutinovic, R Upadhya, JJ Gonzalez, ... Brain, behavior, and immunity 108, 118-134, 2023 | 28 | 2023 |
Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus T Hussain, H Kil, B Hattiangady, J Lee, M Kodali, B Shuai, S Attaluri, ... Neurobiology of disease 121, 163-176, 2019 | 28 | 2019 |
Chronobiology of limbic seizures: Potential mechanisms and prospects of chronotherapy for mesial temporal lobe epilepsy DLG Gitai, TG de Andrade, YDR Dos Santos, S Attaluri, AK Shetty Neuroscience & Biobehavioral Reviews 98, 122-134, 2019 | 23 | 2019 |
Oral nano-curcumin in a model of chronic Gulf War illness alleviates brain dysfunction with modulation of oxidative stress, mitochondrial function, neuroinflammation … S Attaluri, M Arora, LN Madhu, M Kodali, B Shuai, L Melissari, R Upadhya, ... Aging and Disease 13 (2), 583, 2022 | 16 | 2022 |
Moderate, intermittent voluntary exercise in a model of Gulf War Illness improves cognitive and mood function with alleviation of activated microglia and astrocytes, and … M Kodali, V Mishra, B Hattiangady, S Attaluri, JJ Gonzalez, B Shuai, ... Brain, behavior, and immunity 97, 135-149, 2021 | 12 | 2021 |
Brain-specific increase in leukotriene signaling accompanies chronic neuroinflammation and cognitive impairment in a model of Gulf war illness S Attaluri, R Upadhya, M Kodali, LN Madhu, D Upadhya, B Shuai, ... Frontiers in Immunology 13, 853000, 2022 | 9 | 2022 |
Intranasally administered extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells quickly incorporate into neurons and microglia in 5xFAD mice S Attaluri, J Jaimes Gonzalez, M Kirmani, AD Vogel, R Upadhya, M Kodali, ... Frontiers in Aging Neuroscience 15, 1200445, 2023 | 7 | 2023 |
Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy D Upadhya, S Attaluri, Y Liu, B Hattiangady, OW Castro, B Shuai, Y Dong, ... npj Regenerative Medicine 7 (1), 38, 2022 | 7 | 2022 |
A single intranasal dose of human mesenchymal stem cell-derived extracellular vesicles after traumatic brain injury eases neurogenesis decline, synapse loss, and BDNF-ERK-CREB … M Kodali, LN Madhu, RL Reger, B Milutinovic, R Upadhya, S Attaluri, ... Frontiers in Molecular Neuroscience 16, 1185883, 2023 | 4 | 2023 |
Extracellular vesicles from hiPSC-NSCs can prevent peripheral inflammation-induced cognitive dysfunction with inflammasome inhibition and improved neurogenesis in the hippocampus G Ayyubova, M Kodali, R Upadhya, LN Madhu, S Attaluri, Y Somayaji, ... Journal of Neuroinflammation 20 (1), 297, 2023 | 1 | 2023 |
Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer's Model LN Madhu, M Kodali, R Upadhya, S Rao, B Shuai, Y Somayaji, S Attaluri, ... bioRxiv, 2024.01. 18.576313, 2024 | | 2024 |