Narcolepsy: Mending a broken neural circuit that controls arousal

Giancarlo Vanini

doi:10.1016/j.cub.2023.02.053

Narcolepsy: Mending a broken neural circuit that controls arousal

Curr Biol. 2023 Apr 24;33(8):R316-R318. doi: 10.1016/j.cub.2023.02.053.

Author

Giancarlo Vanini¹

Affiliation

¹ Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA; Center for Consciousness Science, University of Michigan, Ann Arbor, MI 48109, USA; Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: gvanini,@,umich.edu.

PMID: 37098337
DOI: 10.1016/j.cub.2023.02.053

Abstract

Narcolepsy is a sleep disorder caused by insufficient levels of orexins, with current treatment options addressing symptoms rather than etiology. New research reveals that transplantation of orexin cells in a mouse model of narcolepsy reduces cataplexy.

MeSH terms

Animals
Arousal
Cataplexy*
Disease Models, Animal
Mice
Narcolepsy*
Neurons
Orexins

Substances

Orexins