Improving the accuracy of adherence data collected using medication monitoring technology in clinical research

Contemp Clin Trials. 2023 Feb:125:107051. doi: 10.1016/j.cct.2022.107051. Epub 2022 Dec 15.

Abstract

Ambiguous adherence data adversely effects the statistical analyses, study conclusions, and generalizability of research findings for clinical trials. Fortunately, technology-based measures of drug dosing provide more objective measures of medication adherence. While adherence data obtained through monitoring technology avoids the well documented shortcomings of self-reported adherence data, there are important limitations and nuances with use of these technologies that should be considered at study inception, conduct, and analysis. This article describes considerations for data collection and management with use of electronic adherence monitoring, specifically mobile-phone video applications or electronic pillbox devices. The overall aim of this communique is to provide research teams the ability to collect more accurate adherence data and ultimately improve the quality and outcome of their research.

Keywords: Adherence; Electronic; Guidance; Medical technology; Medication adherence monitoring; Wireless technology.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Phone*
  • Drug Monitoring
  • Humans
  • Medication Adherence
  • Mobile Applications*
  • Telemedicine*