Local recruitment and fueling of the cellular powerplant to support cell invasion

Nathaniel Shannon; Brian Cunniff

doi:10.1016/j.devcel.2022.03.002

Local recruitment and fueling of the cellular powerplant to support cell invasion

Dev Cell. 2022 Mar 28;57(6):689-690. doi: 10.1016/j.devcel.2022.03.002.

Authors

Nathaniel Shannon¹, Brian Cunniff²

Affiliations

¹ Department of Pathology and Laboratory Medicine, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT 05405, USA; University of Vermont Cancer Center, Burlington, VT 05405, USA.
² Department of Pathology and Laboratory Medicine, The Robert Larner M.D. College of Medicine, University of Vermont, Burlington, VT 05405, USA; University of Vermont Cancer Center, Burlington, VT 05405, USA. Electronic address: bcunniff@uvm.edu.

PMID: 35349795
DOI: 10.1016/j.devcel.2022.03.002

Abstract

In this issue of Developmental Cell, Garde et al. demonstrate that polarized expression of the glucose transporter FGT-1, accompanied by a localized glucose gradient and mitochondrial recruitment to the basal membrane of the anchor cell (AC), supports localized ATP generation required for basement membrane (BM) invasion in C. elegans.

Publication types

Comment

MeSH terms

Actins / metabolism
Adenosine Triphosphate / metabolism
Animals
Basement Membrane / metabolism
Caenorhabditis elegans Proteins* / metabolism
Caenorhabditis elegans* / metabolism
Cell Movement
Glucose / metabolism
Glucose Transport Proteins, Facilitative / metabolism
Mitochondria / metabolism

Substances

Actins
Caenorhabditis elegans Proteins
FGT-1 protein, C elegans
Glucose Transport Proteins, Facilitative
Adenosine Triphosphate
Glucose