Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study

Purpose: To describe the management of arterial partial pressure of carbon dioxide (PaCO₂) in severe traumatic brain-injured (TBI) patients, and the optimal target of PaCO₂ in patients with high intracranial pressure (ICP).

Methods: Secondary analysis of CENTER-TBI, a multicentre, prospective, observational, cohort study. The primary aim was to describe current practice in PaCO₂ management during the first week of intensive care unit (ICU) after TBI, focusing on the lowest PaCO₂ values. We also assessed PaCO₂ management in patients with and without ICP monitoring (ICP_m), and with and without intracranial hypertension. We evaluated the effect of profound hyperventilation (defined as PaCO₂ < 30 mmHg) on long-term outcome.

Results: We included 1100 patients, with a total of 11,791 measurements of PaCO₂ (5931 lowest and 5860 highest daily values). The mean (± SD) PaCO₂ was 38.9 (± 5.2) mmHg, and the mean minimum PaCO₂ was 35.2 (± 5.3) mmHg. Mean daily minimum PaCO₂ values were significantly lower in the ICP_m group (34.5 vs 36.7 mmHg, p < 0.001). Daily PaCO₂ nadir was lower in patients with intracranial hypertension (33.8 vs 35.7 mmHg, p < 0.001). Considerable heterogeneity was observed between centers. Management in a centre using profound hyperventilation (HV) more frequently was not associated with increased 6 months mortality (OR = 1.06, 95% CI = 0.77-1.45, p value = 0.7166), or unfavourable neurological outcome (OR 1.12, 95% CI = 0.90-1.38, p value = 0.3138).

Conclusions: Ventilation is manipulated differently among centers and in response to intracranial dynamics. PaCO₂ tends to be lower in patients with ICP monitoring, especially if ICP is increased. Being in a centre which more frequently uses profound hyperventilation does not affect patient outcomes.