Dynamic changes of acquired maternal SARS-CoV-2 IgG in infants

Sci Rep. 2021 Apr 13;11(1):8021. doi: 10.1038/s41598-021-87535-x.

Abstract

At present, there are still ambiguous reports about the perinatal infection of infants born to mothers infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The dynamic characteristics of infantile serum antibodies born to mother with SARS-CoV-2 has not been well described. In this study, we analyzed the seroconversion of 27 newborns born to 26 pregnant women infected with SARS-CoV-2. The SARS-CoV-2 IgG positive rate of parturient was 80.8%, and half of their infants obtained maternal IgG. IgG transfer rates were 18.8% and 81.8% in those infants whose mother infected less and more than 2 weeks before delivery. In the first two months of life, the IgG level of infants dropped sharply to one tenth of that at birth. These results suggest that maternal SARS-CoV-2 IgG provides limited protection for infants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / blood*
  • COVID-19 / diagnosis*
  • COVID-19 / virology
  • Female
  • Gestational Age
  • Humans
  • Immunoassay
  • Immunoglobulin G / blood*
  • Infant
  • Infant, Newborn
  • Male
  • Maternal-Fetal Exchange*
  • Pregnancy
  • RNA, Viral / analysis
  • Real-Time Polymerase Chain Reaction
  • SARS-CoV-2 / genetics
  • SARS-CoV-2 / immunology*
  • SARS-CoV-2 / isolation & purification

Substances

  • Antibodies, Viral
  • Immunoglobulin G
  • RNA, Viral