Buprenorphine Microdose Induction for the Management of Prescription Opioid Dependence

J Am Board Fam Med. 2021 Feb;34(Suppl):S141-S146. doi: 10.3122/jabfm.2021.S1.200236.

Abstract

Prescription opioid dependence remains a major source of morbidity and mortality in the United States. Patients previously on high-dose opioids may poorly tolerate opioid tapers. Current guidelines support the use of buprenorphine therapy in opioid-tapering protocols, even among patients without a diagnosis of opioid use disorder. Buprenorphine microinduction protocols can be used to transition patients to buprenorphine therapy without opioid withdrawal. From November 2019 to April 2020, we transitioned 8 patients on high-dose prescribed opioids for pain to sublingual buprenorphine-naloxone using a microdose protocol without any evidence of precipitated withdrawal. Six of these patients remain on buprenorphine-naloxone and report improved analgesia. Because of its simplicity, the buprenorphine microinduction protocol can be easily adapted for telemedicine and may help to prevent unnecessary clinic visits and opioid-related admissions in the setting of social distancing regulations during the coronavirus 2019 pandemic.

Keywords: Buprenorphine Naloxone; COVID-19; Opioid Addiction; Pain; Pandemics; Telemedicine.

MeSH terms

  • Administration, Sublingual
  • Aged
  • Buprenorphine, Naloxone Drug Combination / administration & dosage*
  • COVID-19
  • Female
  • Humans
  • Male
  • Middle Aged
  • Narcotic Antagonists / administration & dosage*
  • Opioid-Related Disorders / drug therapy*
  • SARS-CoV-2
  • Substance Withdrawal Syndrome / prevention & control
  • Telemedicine / methods

Substances

  • Buprenorphine, Naloxone Drug Combination
  • Narcotic Antagonists